For carded items, I consider an item that is complete and loose, with card to be "opened" even if the bubble is missing. For items I purchase myself, I keep the cardboard insert... but if I buy the things separately, I can consider it "opened" without that insert.
Of course, the database is how you use it. Some people just use the site as a checklist and may add an item to their collection without clicking every box. Or some can be out of date (like mine) as I have opened quite a few of the items in my collection in recent months and not updated my collection to reflect that.